SIRT3-IN-2 (Inhibitor scaffolds in Scheme 1) is a SIRT3 inhibitor with an inhibition rate of 39% at 200 µM. SIRT3-IN-2 is expected to be useful in metabolic homeostasis and tumor suppression studies [1].

Physicochemical Properties

Molecular Formula	C18H13N3O3S
Molecular Weight	351.38
CAS #	848688-62-0
SMILES	C(NC1=CC=CC(O)=C1)(=O)CSC1N=CN=C2C3=C(OC2=1)C=CC=C3
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	SIRT3
References	[1]. Identification of novel SIRT3 inhibitor scaffolds by virtual screening. Bioorg Med Chem Lett. 2013 May 15;23(10):2990-5.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.8459 mL	14.2296 mL	28.4592 mL
	5 mM	0.5692 mL	2.8459 mL	5.6918 mL
	10 mM	0.2846 mL	1.4230 mL	2.8459 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.