SIRT-IN-6 (Compound 14) is a pan-inhibitor of SIRT1/2/3 with IC50 value >50 μM. SIRT-IN-6 has the potential to be used in the study of metabolism, inflammation, tumors and neurodegenerative diseases.

Physicochemical Properties

Molecular Formula	C7H4CLN3OS
Molecular Weight	213.64
CAS #	1431411-18-5
SMILES	ClC1C2=C(C=C(C(N)=O)S2)N=CN=1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	SIRT1 >50 μM (IC50); SIRT2 >50 μM (IC50); SIRT3 >50 μM (IC50)
References	[1]. Discovery of thieno3,2-dpyrimidine-6-carboxamides as potent inhibitors of SIRT1, SIRT2, and SIRT3. J Med Chem. 2013 May 9;56(9):3666-79.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.6808 mL	23.4039 mL	46.8077 mL
	5 mM	0.9362 mL	4.6808 mL	9.3615 mL
	10 mM	0.4681 mL	2.3404 mL	4.6808 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.