Physicochemical Properties
| Molecular Formula | C36H46N4O5 |
| Molecular Weight | 614.77 |
| Exact Mass | 614.346 |
| CAS # | 1656261-09-4 |
| PubChem CID | 90479828 |
| Appearance | Off-white to light yellow solid powder |
| LogP | 6.8 |
| Hydrogen Bond Donor Count | 1 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 13 |
| Heavy Atom Count | 45 |
| Complexity | 962 |
| Defined Atom Stereocenter Count | 1 |
| SMILES | C(C1C=CC(OC)=CC=1N1CCC(COC2N=CC=C([C@H](C3CC3)CC(=O)O)C=2)CC1)(=O)N(C1=CC=CC(C)=N1)CC(C)(C)C |
| InChi Key | VVRXREQIOCYUKN-PMERELPUSA-N |
| InChi Code | InChI=1S/C36H46N4O5/c1-24-7-6-8-32(38-24)40(23-36(2,3)4)35(43)29-12-11-28(44-5)20-31(29)39-17-14-25(15-18-39)22-45-33-19-27(13-16-37-33)30(21-34(41)42)26-9-10-26/h6-8,11-13,16,19-20,25-26,30H,9-10,14-15,17-18,21-23H2,1-5H3,(H,41,42)/t30-/m0/s1 |
| Chemical Name | (S)-3-Cyclopropyl-3-(2-((1-(5-methoxy-2-((6-methylpyridin-2-yl)(neopentyl)carbamoyl)phenyl)piperidin-4-yl)methoxy)pyridin-4-yl)propanoic acid |
| Synonyms | SCO267 SCO 267 SCO-267 |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| Targets |
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| ln Vitro | The Gαq, Gαs, and Gα12/13 pathways, as well as β-Arrestin Recruitment, are activated by SCO-267 (CHO cells). With fasiglifam and an endogenous ligand, SCO-267 exhibits allosteric behavior[1]. | |
| ln Vivo | SCO-267 has a prolonged effect on reducing blood sugar levels and enhances insulin sensitivity (1 or 10 mg/kg; po)[1]. | |
| Animal Protocol |
Animal/Disease Models: N-STZ rats[1] Doses: 1 or 10 mg/kg Route of Administration: Po; Experimental Results: Improved insulin sensitivity and exerted sustained glucose-lowering effect. |
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| References |
[1]. Chronic Exposure to SCO-267, an Allosteric GPR40 Full Agonist, Is Effective in Improving Glycemic Control in Rats. Mol Pharmacol. 2021 Apr;99(4):286-293. |
Solubility Data
| Solubility (In Vitro) | DMSO : ~100 mg/mL (~162.66 mM) |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (4.07 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.6266 mL | 8.1331 mL | 16.2662 mL | |
| 5 mM | 0.3253 mL | 1.6266 mL | 3.2532 mL | |
| 10 mM | 0.1627 mL | 0.8133 mL | 1.6266 mL |