SC-VC-PAB-N-Me-L-Ala-Maytansinol (compound B1) may be utilized to prepare MCC-Maytansinoid. SC-VC-PAB-N-Me-L-Ala-Maytansinol can be used as a control compound in cancer-related research.

Physicochemical Properties

Molecular Formula	C65H89CLN10O20
Molecular Weight	1365.91
CAS #	2226467-76-9
PubChem CID	155091914
Appearance	White to off-white solid powder
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	20
Rotatable Bond Count	29
Heavy Atom Count	96
Complexity	2860
Defined Atom Stereocenter Count	10
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. BISPECIFIC ANTIGEN BINDING MOLECULES THAT BIND HER2, AND METHODS OF USE THEREOF. WO2021174113. 2021.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (73.21 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (1.83 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (1.83 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.7321 mL	3.6606 mL	7.3211 mL
	5 mM	0.1464 mL	0.7321 mL	1.4642 mL
	10 mM	0.0732 mL	0.3661 mL	0.7321 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.