SARS-CoV-2 Mpro-IN-29 (Compound 7) is an inhibitor of SARS-CoV-2 main protease (Mpro) with an IC50 of 310 nM for Mpro and an EC50 of 0.5 μM in Vero cells. SARS-CoV-2 Mpro-IN-29 binds to the active site of Mpro, preventing the cleavage of viral polyproteins, exhibiting significant antiviral activity and metabolic enhancement. SARS-CoV-2 Mpro-IN-29 is expected to be used in the research of SARS-CoV-2 antiviral drugs.

Physicochemical Properties

Molecular Formula	C22H27N4NAO7S2
Molecular Weight	546.59
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Peptide Aldehydes Incorporating Thiazol-4-yl Alanine Are Potent In Vitro Inhibitors of SARS-CoV-2 Main Protease. ACS Med Chem Lett. 2024 Nov 3;15(11):2046-2052.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.8295 mL	9.1476 mL	18.2952 mL
	5 mM	0.3659 mL	1.8295 mL	3.6590 mL
	10 mM	0.1830 mL	0.9148 mL	1.8295 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.