SARS-CoV-2-IN-108 (Compound 29) is an inhibitor of SARSCoV-2 papain-like protease with IC50 of 0.14 µM. SARS-CoV-2-IN-108 inhibits viral replication with EC50 of 0.21 µM.

Physicochemical Properties

Molecular Formula	C28H29N3O5S
Molecular Weight	519.61
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Synthesis and Structure-Activity Relationship of Covalent Inhibitors of SARS-CoV-2 Papain-Like Protease with Antiviral Potency. Bioorg Med Chem Lett. 2025 Feb 1;116:130034.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.9245 mL	9.6226 mL	19.2452 mL
	5 mM	0.3849 mL	1.9245 mL	3.8490 mL
	10 mM	0.1925 mL	0.9623 mL	1.9245 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.