SARS-CoV-2-IN-107 (Compound A7) is an inhibitor of SARS-CoV-2 3CLpro with IC50 of 261.3 nM. SARS-CoV-2-IN-107 inhibits SARS-CoV-2 replication with EC50 of 11.7 μM. SARS-CoV-2-IN-107 exhibits anti-inflammatory activity in LPS-stimulated RAW264.7 macrophages with a NO inhibition rate of 68.6%.

Physicochemical Properties

Molecular Formula	C15H11FO4
Molecular Weight	274.24
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Discovery of Chalcone Derivatives as Bifunctional Molecules with Anti-SARS-CoV-2 and Anti-inflammatory Activities. J Nat Prod. 2024 Dec 27;87(12):2680-2694.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.6464 mL	18.2322 mL	36.4644 mL
	5 mM	0.7293 mL	3.6464 mL	7.2929 mL
	10 mM	0.3646 mL	1.8232 mL	3.6464 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.