SARS-CoV-2-IN-106 (compound 19) is a SARS-CoV-2 papain inhibitor with IC50 values of 0.44 μM and 0.18 μM for papain and viral replication, respectively.

Physicochemical Properties

Molecular Formula	C31H38FN5O2
Molecular Weight	531.66
CAS #	2863607-73-0
SMILES	[C@H](N1CCC(CC1)C(=O)NCC1C=C(C=C(C=1)NC(N1CCN(CC1)C)=O)F)(C1=CC=CC2C=CC=CC1=2)C
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. Cell Chem Biol. 2021;28(6):855-865.e9.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.8809 mL	9.4045 mL	18.8090 mL
	5 mM	0.3762 mL	1.8809 mL	3.7618 mL
	10 mM	0.1881 mL	0.9405 mL	1.8809 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.