SAHA chloroalkane T1 is a capture label conjugated by Vorinostat (SAHA) and a chloroalkane T1 chain.

Physicochemical Properties

Molecular Formula	C33H55CLN4O11
Molecular Weight	719.263009309769
Exact Mass	718.355
CAS #	1613617-05-2
PubChem CID	86274259
Appearance	White to off-white solid powder
LogP	2.3
Hydrogen Bond Donor Count	5
Hydrogen Bond Acceptor Count	11
Rotatable Bond Count	33
Heavy Atom Count	49
Complexity	852
Defined Atom Stereocenter Count	0
InChi Key	QJTGTGYXESVKJU-UHFFFAOYSA-N
InChi Code	InChI=1S/C33H55ClN4O11/c34-15-7-3-4-8-17-44-19-20-45-18-16-35-32(41)48-25-23-46-21-22-47-24-26-49-33(42)36-27-28-11-13-29(14-12-28)37-30(39)9-5-1-2-6-10-31(40)38-43/h11-14,43H,1-10,15-27H2,(H,35,41)(H,36,42)(H,37,39)(H,38,40)
Chemical Name	2-[2-[2-[[4-[[8-(hydroxyamino)-8-oxooctanoyl]amino]phenyl]methylcarbamoyloxy]ethoxy]ethoxy]ethyl N-[2-[2-(6-chlorohexoxy)ethoxy]ethyl]carbamate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	SAHA Chlorane T1 has minimal impact on the efficacy of SAHA in K-562 cells, allowing binding interactions with targets to occur under conditions appropriate to the desired cell phenotype [1].
References	[1]. Deciphering the Cellular Targets of Bioactive Compounds Using a Chloroalkane Capture Tag. ACS Chem Biol. 2015 Oct 16;10(10):2316-24.

Solubility Data

Solubility (In Vitro)

DMSO : ~125 mg/mL (~173.79 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (2.89 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.3903 mL	6.9516 mL	13.9032 mL
	5 mM	0.2781 mL	1.3903 mL	2.7806 mL
	10 mM	0.1390 mL	0.6952 mL	1.3903 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.