S1b3inL1 is a macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein. S1b3inL1 can bind to the conserved site of the spike protein with high affinity and inhibit the infection of multiple SARS-CoV-2 variants. S1b3inL1 has antiviral activity.

Physicochemical Properties

Molecular Formula	C103H158N30O24S
Molecular Weight	2232.61
CAS #	3027437-21-1
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. A broad-spectrum macrocyclic peptide inhibitor of the SARS-CoV-2 spike protein. Proc Natl Acad Sci U S A. 2023 Jun 27;120(26):e2303292120.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.4479 mL	2.2395 mL	4.4791 mL
	5 mM	0.0896 mL	0.4479 mL	0.8958 mL
	10 mM	0.0448 mL	0.2240 mL	0.4479 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.