(S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran (compound 2d), a halogenated phenadrine analog, is a microtubule destabilizing agent. (S)-3-(4-(2-Chloro-5-iodobenzyl)phenoxy)tetrahydrofuran has anticancer activity.

Physicochemical Properties

Molecular Formula	C17H16CLIO2
Molecular Weight	414.67
CAS #	915095-94-2
Appearance	White to off-white solid powder
SMILES	C(C1C=CC(O[C@@H]2COCC2)=CC=1)C1C=C(I)C=CC=1Cl
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Design, synthesis and anticancer activities of halogenated Phenstatin analogs as microtubule destabilizing agent. Med Chem Res 28, 465–472 (2019).

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.4116 mL	12.0578 mL	24.1156 mL
	5 mM	0.4823 mL	2.4116 mL	4.8231 mL
	10 mM	0.2412 mL	1.2058 mL	2.4116 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.