Ruzinurad (HR011303) is a selective URATl inhibitor (WO2020088641, compound I). Ruzinurad may be utilized in study/research of hyperuricemia.

Physicochemical Properties

Molecular Formula	C14H12BRNO2S
Molecular Weight	338.22
Exact Mass	336.977
CAS #	1638327-48-6
PubChem CID	86294127
Appearance	White to off-white solid powder
Density	1.7±0.1 g/cm3
Boiling Point	528.9±40.0 °C at 760 mmHg
Flash Point	273.7±27.3 °C
Vapour Pressure	0.0±1.5 mmHg at 25°C
Index of Refraction	1.730
LogP	3.12
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	3
Heavy Atom Count	19
Complexity	361
Defined Atom Stereocenter Count	0
InChi Key	QGBWIYLNOBYNDL-UHFFFAOYSA-N
InChi Code	InChI=1S/C14H12BrNO2S/c15-9-2-3-11-10(8-9)12(4-7-16-11)19-14(13(17)18)5-1-6-14/h2-4,7-8H,1,5-6H2,(H,17,18)
Chemical Name	1-(6-bromoquinolin-4-yl)sulfanylcyclobutane-1-carboxylic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	URAT1[1]
ln Vitro	Ruzinurad is an extremely effective inhibitor of URATl [1].
References	[1]. WO2020088641.

Solubility Data

Solubility (In Vitro)

DMSO: 33.33 mg/mL (98.55 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 1 mg/mL (2.96 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 10.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.9567 mL	14.7833 mL	29.5666 mL
	5 mM	0.5913 mL	2.9567 mL	5.9133 mL
	10 mM	0.2957 mL	1.4783 mL	2.9567 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.