Physicochemical Properties
| Molecular Formula | C17H18CLN3O |
| Molecular Weight | 315.801 |
| Exact Mass | 315.113 |
| Elemental Analysis | C, 64.66; H, 5.75; Cl, 11.23; N, 13.31; O, 5.07 |
| CAS # | 132907-72-3 |
| Related CAS # | 132907-72-3 (HCl); 132036-88-5 |
| PubChem CID | 107999 |
| Appearance | White to off-white solid powder |
| Boiling Point | 579.7ºC at 760mmHg |
| Melting Point | 244-246°C |
| Flash Point | 304.4ºC |
| Vapour Pressure | 1.96E-13mmHg at 25°C |
| LogP | 3.691 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 2 |
| Heavy Atom Count | 22 |
| Complexity | 413 |
| Defined Atom Stereocenter Count | 1 |
| SMILES | Cl[H].O=C(C1=C([H])N(C([H])([H])[H])C2=C([H])C([H])=C([H])C([H])=C12)[C@@]1([H])C([H])([H])C2=C(C([H])([H])C1([H])[H])N=C([H])N2[H] |
| InChi Key | XIXYTCLDXQRHJO-RFVHGSKJSA-N |
| InChi Code | InChI=1S/C17H17N3O.ClH/c1-20-9-13(12-4-2-3-5-16(12)20)17(21)11-6-7-14-15(8-11)19-10-18-14;/h2-5,9-11H,6-8H2,1H3,(H,18,19);1H/t11-;/m1./s1 |
| Chemical Name | (1-methylindol-3-yl)-[(5R)-4,5,6,7-tetrahydro-3H-benzimidazol-5-yl]methanone;hydrochloride |
| Synonyms | YM-060; YM 060; YM060; Ramosetron hydrochloride; Ramosetron HCl |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| Targets | 5-HT3 receptor ( Ki = 0.091 nM ) |
| ln Vitro | Ramosetron Hydrochloride (YM-060) has very low afinity for nicotinic and GABA receptors. YM060 also exhibits low affinity for histamine H1 and H2 receptors, alpha-1, atpha-2, beta-1, beta-2, and 5-HT1-like and 5-HT2 receptors, according to in vitro research. Anticipated 5-HT4 receptor blocking activity of YM-060 is negative[2]. |
| ln Vivo | Ramosetron has been shown to potently inhibit abnormal defecation in animals that is caused by stress. Ramosetron has potent, rapid-onset, and long-lasting inhibitory effects on rats' CFS-induced defecation, but has no effect on regular defecation. Ramosetron's inhibitory effect started to take effect right away after dosage and persisted for several hours[1]. |
| Animal Protocol |
Sprague-Dawley rats 0.01, 0.03, 0.1 mg/kg oral |
| References |
[1]. J Pharmacol Sci . 2008 Feb;106(2):264-70. [2]. J Pharmacol Exp Ther . 1992 Dec;263(3):1127-32. |
| Additional Infomation |
Ramosetron hydrochloride is a member of indoles. Ramosetron Hydrochloride is the hydrochloride salt of ramosetron, a selective serotonin (5-HT) receptor antagonist with potential antiemetic activity. Upon administration, ramosetron selectively binds to and blocks the activity of 5-HT subtype 3 (5-HT3) receptors located in the vagus nerve terminal and in the vomiting center in the central nervous system (CNS), suppressing chemotherapy-induced nausea and vomiting. |
Solubility Data
| Solubility (In Vitro) |
DMSO: 32~63 mg/mL (101.3~199.5 mM) Water: ~63 mg/mL Ethanol: ~1 mg/mL |
| Solubility (In Vivo) |
Solubility in Formulation 1: 25 mg/mL (79.16 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication (<60°C). (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 3.1666 mL | 15.8328 mL | 31.6656 mL | |
| 5 mM | 0.6333 mL | 3.1666 mL | 6.3331 mL | |
| 10 mM | 0.3167 mL | 1.5833 mL | 3.1666 mL |