Ramipril diketopiperazine is an impurity in the ACE inhibitor Ramipril.

Physicochemical Properties

Molecular Formula	C23H30N2O4
Molecular Weight	398.50
CAS #	108731-95-9
SMILES	CCOC([C@H](N1[C@@H](C)C(=O)N2[C@H]3CCC[C@H]3C[C@H]2C1=O)CCC1C=CC=CC=1)=O
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Development of a capillary electrophoresis method for the assay of ramipril and its impurities: an issue of cis-trans isomerization. J Chromatogr A. 2011 May 6;1218(18):2611-7.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.5094 mL	12.5471 mL	25.0941 mL
	5 mM	0.5019 mL	2.5094 mL	5.0188 mL
	10 mM	0.2509 mL	1.2547 mL	2.5094 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.