RU-0415529 is an orally active SARS-CoV-2 nonstructural protein 14 (NSP14) inhibitor with an IC50 of 356 nM. RU-0415529 inhibits viral RNA methylation and viral replication by binding to the SAH-stabilized cap-binding pocket. RU-0415529 exhibits anti-infective activity in mouse models.

Physicochemical Properties

Molecular Formula	C21H29N3O4S
Molecular Weight	419.54
CAS #	1358734-35-6
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Small-molecule inhibition of SARS-CoV-2 NSP14 RNA cap methyltransferase. Nature. 2024 Dec 11.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3836 mL	11.9178 mL	23.8356 mL
	5 mM	0.4767 mL	2.3836 mL	4.7671 mL
	10 mM	0.2384 mL	1.1918 mL	2.3836 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.