RGD Trifluoroacetate is a tripeptide that can effectively cause cell adhesion, localize to a specific cell line and produce specific cellular responses; RGD Trifluoroacetate can bind to integrins.

Physicochemical Properties

Molecular Formula	C14H23F3N6O8
Molecular Weight	460.363033533096
Exact Mass	460.152
CAS #	2378808-45-6
Related CAS #	RGD;99896-85-2
PubChem CID	132472231
Appearance	White to off-white solid powder
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	13
Rotatable Bond Count	11
Heavy Atom Count	31
Complexity	588
Defined Atom Stereocenter Count	2
SMILES	FC(C(=O)O)(F)F.O=C([C@H](CCC/N=C(\N)/N)N)NCC(N[C@H](C(=O)O)CC(=O)O)=O
InChi Key	FBPDETPEHPAQDC-LEUCUCNGSA-N
InChi Code	InChI=1S/C12H22N6O6.C2HF3O2/c13-6(2-1-3-16-12(14)15)10(22)17-5-8(19)18-7(11(23)24)4-9(20)21;3-2(4,5)1(6)7/h6-7H,1-5,13H2,(H,17,22)(H,18,19)(H,20,21)(H,23,24)(H4,14,15,16);(H,6,7)/t6-,7-;/m0./s1
Chemical Name	(2S)-2-[[2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]acetyl]amino]butanedioic acid;2,2,2-trifluoroacetic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	Integrin[1]
ln Vitro	For enhanced cell attachment on synthetic surfaces, RGD Trifluoroacetate is the most popular and successful peptide sequence. α3β1, α5β1, α8β1, αIIbβ3, αvβ1, αvβ3, αvβ5, αvβ6, αvβ8, and to some extent α2β1 and α4β1 are the 24 integrins that bind to ECM molecules in an RGD dependent manner[1].
References	[1]. RGD modified polymers: biomaterials for stimulated cell adhesion and beyond. Biomaterials. 2003 Nov;24(24):4385-415.

Solubility Data

Solubility (In Vitro)	H2O : ≥ 60 mg/mL (130.33 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (217.22 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.1722 mL	10.8611 mL	21.7221 mL
	5 mM	0.4344 mL	2.1722 mL	4.3444 mL
	10 mM	0.2172 mL	1.0861 mL	2.1722 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.