Purinostat is a selective inhibitor of HDAC I/IIb with anti-leukemic activity. Purinostat mesylate, the mesylate salt form of Purinostat, inhibits the survival of Ph+ leukemic cells and CD34+ leukemic cells derived from CML patients. Purinostat mesylate targets HDAC I/IIb to inhibit several important factors for the survival of leukemic stem cells (LSCs), including c-Myc, β-Catenin, E2f, Ezh2, Alox5, and mTOR. Purinostat mesylate increases glutamate metabolism in LSCs by increasing GLS1.

Physicochemical Properties

Molecular Formula	C23H26N10O3
Molecular Weight	490.52
CAS #	1929583-17-4
Related CAS #	Purinostat mesylate;2650188-32-0
Appearance	Solid powder
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	HDAC1 HDAC2
References	[1]. HDAC I/IIb selective inhibitor Purinostat Mesylate combined with GLS1 inhibition effectively eliminates CML stem cells. Bioact Mater. 2022 Sep 18;21:483-498.

Solubility Data

Solubility (In Vitro)

DMSO : ~125 mg/mL (~254.83 mM; with ultrasonication)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.0387 mL	10.1933 mL	20.3865 mL
	5 mM	0.4077 mL	2.0387 mL	4.0773 mL
	10 mM	0.2039 mL	1.0193 mL	2.0387 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.