Purine riboside-5'-O-triphosphate sodium is an active metabolite of Nebularine (HY -103694) and acts as an inhibitor of DNA primase ATP and GTP polymerization activities with IC50 values of 35 µM and 28 µM, respectively. Purine riboside-5'-O-triphosphate sodium inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 µM.

Physicochemical Properties

Molecular Formula	C10H11N4NA4O13P3
Molecular Weight	580.09
CAS #	35892-95-6
Related CAS #	Purine riboside triphosphate;23197-96-8
Synonyms	PTP tetrasodium
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. ATP depletion, purine riboside triphosphate accumulation and rat thymocyte death induced by purine riboside. Toxicol Lett. 1999;104(3):171-181. [2]. Human DNA primase uses Watson-Crick hydrogen bonds to distinguish between correct and incorrect nucleoside triphosphates. Biochemistry. 2004;43(38):12367-12374. [3]. Mapping of the adenosine 5'-triphosphate binding site of type II calmodulin-dependent protein kinase. Biochemistry. 1987;26(24):7636-7640.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7239 mL	8.6194 mL	17.2387 mL
	5 mM	0.3448 mL	1.7239 mL	3.4477 mL
	10 mM	0.1724 mL	0.8619 mL	1.7239 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.