Physicochemical Properties
| Molecular Weight | 0 |
| Exact Mass | 6687.466 |
| CAS # | 9009-65-8 |
| Appearance | White to off-white solid powder |
| Density | 2.2±0.1 g/cm3 |
| Boiling Point | 330.0±11.0 °C at 760 mmHg |
| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
| Index of Refraction | 1.537 |
| LogP | -1.03 |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture. |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| ln Vitro | When thrombin converts fibrinogen to fibrin, protonate sulfate inhibits it. This inhibition is partial, reversible, and concentration-dependent [3]. Derived from salmon sperm, protonate sulfate is a 5-kDa cationic peptide that binds negatively charged unfractionated heparin (UFH). By preventing factor V activation, protonate sulfate inhibits the production of thrombin [4]. |
| ln Vivo | Animal cystitis models can be created with the use of propetamine sulfate in animal modeling. |
| References |
[1]. Protamine Sulfate Neutralization Profile of Various Dosages of Bovine, Ovine and Porcine UFHs and Their Depolymerized Derivatives in Non-Human Primates. Clin Appl Thromb Hemost. Jan-Dec 2021;27:10760296211005544. [2]. Protamine sulfate enhances lipid-mediated gene transfer. Gene Ther. 1997 Sep;4(9):961-8. [3]. Interaction of protamine sulfate with thrombin. Am J Hematol. 1983 May;14(3):227-33. [4]. Protamine sulfate down-regulates thrombin generation by inhibiting factor V activation. Blood. 2009 Aug 20;114(8):1658-65. [5]. Therapeutic effect of urine-derived stem cells for protamine/lipopolysaccharide-induced interstitial cystitis in a rat model. Stem Cell Res Ther. 2017 May 8;8(1):107. |
Solubility Data
| Solubility (In Vitro) | H2O: 50 mg/mL |
| Solubility (In Vivo) |
Solubility in Formulation 1: 33.33 mg/mL (Infinity mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication. (Please use freshly prepared in vivo formulations for optimal results.) |