Potassium guaiacolsulfonate hemihydrate is an orally bioactive expectorant indicated for acute respiratory tract infections. Potassium guaiacolsulfonate hemihydrate helps loosen mucus and, in combination with other active molecules, may be utilized to treat coughs caused by the common cold, infection, or allergies.

Physicochemical Properties

Molecular Formula	C7H8O5S.1/2H2O.K
Molecular Weight	251.31
Exact Mass	501.94
CAS #	78247-49-1
Appearance	Typically exists as solid at room temperature
LogP	2.707
SMILES	C1(S([O-])(=O)=O)=CC=C(O)C(OC)=C1.[K+].C1(S([O-])(=O)=O)=CC=C(O)C(OC)=C1.[K+].O
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro

In order to make coughing up mucus (phlegm) less sticky and easier, potassium guaiacolsulfonate hemihydrate thins it out in the lungs[1].

References

[1]. Thi Huong Hoa Le, et al. Development and Validation of an HPLC Method for Simultaneous Assay of Potassium Guaiacolsulfonate and Sodium Benzoate in Pediatric Oral Powder. J Anal Methods Chem. 2019 Mar 7;2019:6143061. [2]. Ozlem Aksu Dönmez, et al. Simultaneous Determination of Potassium Guaiacolsulfonate, Guaifenesin, Diphenhydramine HCl and Carbetapentane Citrate in Syrups by Using HPLC-DAD Coupled With Partial Least Squares Multivariate Calibration. Talanta. 2011 Feb 15;83(5):1601-5.

Solubility Data

Solubility (In Vitro)	H2O : 62.5 mg/mL (248.70 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (397.91 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.9791 mL	19.8957 mL	39.7915 mL
	5 mM	0.7958 mL	3.9791 mL	7.9583 mL
	10 mM	0.3979 mL	1.9896 mL	3.9791 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.