Physicochemical Properties
| Molecular Formula | C26H50O10 |
| Molecular Weight | 522.6692 |
| Exact Mass | 604.418 |
| CAS # | 9005-64-5 |
| Related CAS # | 9005-66-7;9005-64-5 |
| PubChem CID | 443314 |
| Appearance | Colorless to light yellow viscous liquid |
| Density | 1.1±0.1 g/cm3 |
| Boiling Point | 695.8±55.0 °C at 760 mmHg |
| Flash Point | 207.1±25.0 °C |
| Vapour Pressure | 0.0±5.0 mmHg at 25°C |
| Index of Refraction | 1.502 |
| LogP | 5.37 |
| Hydrogen Bond Donor Count | 3 |
| Hydrogen Bond Acceptor Count | 10 |
| Rotatable Bond Count | 26 |
| Heavy Atom Count | 36 |
| Complexity | 507 |
| Defined Atom Stereocenter Count | 0 |
| SMILES | O1C([H])([H])C([H])(C([H])(C1([H])C([H])(C([H])([H])OC([H])([H])C([H])([H])OC(C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H])=O)OC([H])([H])C([H])([H])O[H])OC([H])([H])C([H])([H])O[H])OC([H])([H])C([H])([H])O[H] |
| InChi Key | HMFKFHLTUCJZJO-UHFFFAOYSA-N |
| InChi Code | InChI=1S/C26H50O10/c1-2-3-4-5-6-7-8-9-10-11-24(30)34-19-18-31-20-22(32-15-12-27)26-25(35-17-14-29)23(21-36-26)33-16-13-28/h22-23,25-29H,2-21H2,1H3 |
| Chemical Name | 2-[2-[3,4-bis(2-hydroxyethoxy)oxolan-2-yl]-2-(2-hydroxyethoxy)ethoxy]ethyl dodecanoate |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| ln Vitro | By altering granules' surface characteristics, Tween 20 can reduce ineffective protein adsorption by altering surface adsorption, hydrogen bonding ability, and adsorption [1]. The apparent solubility of the medication can be greatly increased from 0.8 μg/mL to 353 μg/mL when Tween 20 (0.35%-0.7% w/w) is added to 0.05 mol/L pH 6.5 phosphate buffer. However, its effect is less pronounced at lower pH values or in water (20 μg/mL at pH 4.5). The solubility of candesartan medoxomil increased to 620 μg/mL when the phosphate concentration (0.2 M) was increased at pH 6.5 in the presence of 0.7% polysorbate 20 [2]. |
| References |
[1]. Evaluation of the action of Tween 20 non-ionic surfactant during enzymatic hydrolysis of lignocellulose: Pretreatment, hydrolysis conditions and lignin structure. Bioresour Technol. 2018 Dec;269:329-338. [2]. The effect of polysorbate 20 on solubility and stability of candesartan cilexetil in dissolution media. AAPS PharmSciTech. 2014 Oct;15(5):1116-25. [3]. Micelle formation of Tween 20 nonionic surfactant in imidazolium ionic liquids. Colloids and Surfaces A: Physicochemical and Engineering Aspects. Volume 471, 20 April 2015, Pages 26-37. |
| Additional Infomation |
Sorbitan mono-9-octadecanoate poly(oxy-1,2-ethanediyl) derivatives; complex mixtures of polyoxyethylene ethers used as emulsifiers or dispersing agents in pharmaceuticals. See also: PEG-80 Sorbitan laurate (annotation moved to); Polysorbate 20 (annotation moved to). |
Solubility Data
| Solubility (In Vitro) | DMSO : ~50 mg/mL |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 1.67 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 16.7 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 1.9133 mL | 9.5663 mL | 19.1325 mL | |
| 5 mM | 0.3827 mL | 1.9133 mL | 3.8265 mL | |
| 10 mM | 0.1913 mL | 0.9566 mL | 1.9133 mL |