Physicochemical Properties
| Molecular Formula | C18H38N6O4 |
| Molecular Weight | 402.5321 |
| Exact Mass | 226.032 |
| CAS # | 25988-63-0 |
| Related CAS # | Poly-L-lysine hydrobromide (MW 30000-70000);25988-63-0;Poly-L-lysine hydrochloride;26124-78-7;Poly-L-lysine hydrobromide (MW 70000-150000);25988-63-0;Poly-L-lysine hydrobromide (MW ＞300000);25988-63-0 |
| PubChem CID | 72363 |
| Appearance | White to off-white solid powder |
| Density | 1.156g/cm3 |
| Boiling Point | 745.4ºC at 760mmHg |
| Flash Point | 404.6ºC |
| Vapour Pressure | 1.24E-05mmHg at 25°C |
| LogP | 1.886 |
| Hydrogen Bond Donor Count | 7 |
| Hydrogen Bond Acceptor Count | 8 |
| Rotatable Bond Count | 17 |
| Heavy Atom Count | 28 |
| Complexity | 463 |
| Defined Atom Stereocenter Count | 3 |
| SMILES | C(CCN)C[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)N |
| InChi Key | WBSCNDJQPKSPII-KKUMJFAQSA-N |
| InChi Code | InChI=1S/C18H38N6O4/c19-10-4-1-7-13(22)16(25)23-14(8-2-5-11-20)17(26)24-15(18(27)28)9-3-6-12-21/h13-15H,1-12,19-22H2,(H,23,25)(H,24,26)(H,27,28)/t13-,14-,15-/m0/s1 |
| Chemical Name | (2S)-6-amino-2-[[(2S)-6-amino-2-[[(2S)-2,6-diaminohexanoyl]amino]hexanoyl]amino]hexanoic acid |
| HS Tariff Code | 2934.99.9001 |
| Storage |
Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light. |
| Shipping Condition | Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs) |
Biological Activity
| References |
[1]. Three archetypical classes of macromolecular regulators of protein liquid-liquid phase separation. Proc Natl Acad Sci U S A. 2019;116(39):19474-19483. |
| Additional Infomation |
Lys-Lys-Lys is an oligopeptide. See also: Poly(L-lysine) hydrobromide (annotation moved to). |
Solubility Data
| Solubility (In Vitro) | H2O : ~125 mg/mL |
| Solubility (In Vivo) |
Solubility in Formulation 1: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. (Please use freshly prepared in vivo formulations for optimal results.) |
| Preparing Stock Solutions | 1 mg | 5 mg | 10 mg | |
| 1 mM | 2.4843 mL | 12.4214 mL | 24.8429 mL | |
| 5 mM | 0.4969 mL | 2.4843 mL | 4.9686 mL | |
| 10 mM | 0.2484 mL | 1.2421 mL | 2.4843 mL |