Polθ-IN-7 (example 12) is a DNA polymerase θ (Polθ) inhibitor with Ki of 1.27 nM.

Physicochemical Properties

Molecular Formula	C28H35F3N6O2
Molecular Weight	544.61
CAS #	2923356-52-7
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Heterocyclic compounds for use in the treatment of cancer. WO2023067355A1.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.8362 mL	9.1809 mL	18.3618 mL
	5 mM	0.3672 mL	1.8362 mL	3.6724 mL
	10 mM	0.1836 mL	0.9181 mL	1.8362 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.