PeptideDB

PhosTAC3

PhosTAC3

CAS No.:

PhosTAC3 is a phosphorylation-targeting chimera (PhosTAC) molecule consisting of a linker and three PEG groups. PhosTAC3
Data collection:peptidedb@qq.com

This product is for research use only, not for human use. We do not sell to patients.

PhosTAC3 is a phosphorylation-targeting chimera (PhosTAC) molecule consisting of a linker and three PEG groups. PhosTAC3 induces dephosphorylation of PDCD4 and FOXO3a.

Physicochemical Properties


Molecular Formula C50H71CLN2O13
Appearance Light brown to brown ointment
HS Tariff Code 2934.99.9001
Storage

Powder-20°C 3 years

4°C 2 years

In solvent -80°C 6 months

-20°C 1 month

Shipping Condition Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity


References

[1]. Modulation of Phosphoprotein Activity by Phosphorylation Targeting Chimeras (PhosTACs). ACS Chem Biol. 2021 Dec 17;16(12):2808-2815.


Solubility Data


Solubility (In Vitro) DMSO :~130 mg/mL (~137.78 mM)
Solubility (In Vivo) Solubility in Formulation 1: ≥ 3.25 mg/mL (3.44 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution.
For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 32.5 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.

 (Please use freshly prepared in vivo formulations for optimal results.)