PTP inhibitor 1 is a protein tyrosine phosphatase (PTP) inhibitor (antagonist) with anti-angiogenic activity.

Physicochemical Properties

Molecular Formula	C9H9BRO2
Molecular Weight	229.0706
Exact Mass	227.978
CAS #	2632-13-5
PubChem CID	4965
Appearance	White to off-white solid powder
Density	1.4±0.1 g/cm3
Boiling Point	306.7±17.0 °C at 760 mmHg
Melting Point	69-71 °C(lit.)
Flash Point	139.3±20.9 °C
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.554
LogP	2.27
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	3
Heavy Atom Count	12
Complexity	151
Defined Atom Stereocenter Count	0
InChi Key	XQJAHBHCLXUGEP-UHFFFAOYSA-N
InChi Code	InChI=1S/C9H9BrO2/c1-12-8-4-2-7(3-5-8)9(11)6-10/h2-5H,6H2,1H3
Chemical Name	2-bromo-1-(4-methoxyphenyl)ethanone
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	PTP inhibitor 1 exhibits an IC50 of 3.7 μM and anti-angiogenic action on HUVEC [1]
References	[1]. Phosphatase inhibitors with anti-angiogenic effect in vitro. APMIS. 2010 Jan;118(1):49-59.

Solubility Data

Solubility (In Vitro)

DMSO : ≥ 100 mg/mL (~436.55 mM) H2O : ~1 mg/mL (~4.37 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (10.91 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (10.91 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution. Solubility in Formulation 3: ≥ 2.5 mg/mL (10.91 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	4.3655 mL	21.8274 mL	43.6548 mL
	5 mM	0.8731 mL	4.3655 mL	8.7310 mL
	10 mM	0.4365 mL	2.1827 mL	4.3655 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.