PTAD-PEG8-alkyne is a cleavable ADC linker used for the synthesis of antibody-coupled active molecules (ADCs).

Physicochemical Properties

Molecular Formula	C31H48N4O13
Molecular Weight	684.73
Appearance	Solid-Liquid Mixture
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Solubility Data

Solubility (In Vitro)

DMSO : ~125 mg/mL (~182.55 mM; with ultrasonication)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.4604 mL	7.3021 mL	14.6043 mL
	5 mM	0.2921 mL	1.4604 mL	2.9209 mL
	10 mM	0.1460 mL	0.7302 mL	1.4604 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.