PROTAC LZK-IN-1 (Compound 21A) is a PROTAC that targets the degradation of LZK (leucine zipper kinase, encoded by MAP3K13). PROTAC LZK-IN-1 (10 μM) promotes LZK degradation and inhibits the expression of p53 and c-MYC, resulting in impaired viability of global head and neck squamous cell carcinoma (HNSCC) cell lines. PROTAC LZK-IN-1 can be used in anti-cancer research. PROTAC LZK-IN-1 consists of an E3 ligase ligand (blue part), a target protein ligand (red part), and a Linker (black part) [1].

Physicochemical Properties

Molecular Formula	C51H64F2N10O5S
Molecular Weight	967.18
CAS #	2763268-64-8
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Targeting GOF p53 and c-MYC through LZK Inhibition or Degradation Suppresses Head and Neck Tumor Growth. bioRxiv Preprint. 2024 Nov 20:2024.11.19.623840.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.0339 mL	5.1697 mL	10.3393 mL
	5 mM	0.2068 mL	1.0339 mL	2.0679 mL
	10 mM	0.1034 mL	0.5170 mL	1.0339 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.