PPL agonist-1 (Compound I-3) is a highly selective Periplakin (PPL) agonist that increases cAMP levels by regulating PPL, thereby enhancing MITF expression and promoting melanin synthesis. In addition, PPL agonist-1 also promotes melanin production by regulating tryptophan metabolism. Compared with Ruxolitinib, PPL agonist-1 shows a more excellent effect. PPL agonist-1 is expected to be used in vitiligo disease research.

Physicochemical Properties

Molecular Formula	C25H22FN5O4S
Molecular Weight	507.54
CAS #	3040997-52-9
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Zhong H, Li P, Yan Q, Xia Y, Zhang X, Lai Y, Li L, Wang F, Shang J, Zha X. Targeting Periplakin of Novel Benzenesulfonamides as Highly Selective Agonists for the Treatment of Vitiligo. J Med Chem. 2024 Nov 14;67(21):19323-19341.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.9703 mL	9.8514 mL	19.7029 mL
	5 mM	0.3941 mL	1.9703 mL	3.9406 mL
	10 mM	0.1970 mL	0.9851 mL	1.9703 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.