PPARγ agonist 16 (Compound 4G) is a PPARγ agonist that competitively binds to the LBD domain of PPARγ with an IC50 of 1790 nM. PPARγ agonist 16 inhibits ear swelling in a mouse model and exhibits antihyperglycemic activity in a streptozotocin-induced mouse diabetes model.

Physicochemical Properties

Molecular Formula	C19H14BRNO4S
Molecular Weight	432.29
CAS #	2218046-01-4
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	PPAR-γ 1790 nM (IC50)
References	[1]. Design, synthesis and bioactivity evaluation of thiazolidinedione derivatives as partial agonists targeting PPARγ. Bioorg Chem. 2021 Nov;116:105342.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3133 mL	11.5663 mL	23.1326 mL
	5 mM	0.4627 mL	2.3133 mL	4.6265 mL
	10 mM	0.2313 mL	1.1566 mL	2.3133 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.