PPARγ agonist 15 (Compound 7c) is a PPARγ agonist. PPARγ agonist 15 inhibits the expression of α-amylase (HPA) and α-glucosidase (HLAG) with IC50 of 28.35 µM and 26.21 µM, respectively. PPARγ agonist 15 increases glucose uptake in L6 myotube cells. PPARγ agonist 15 improves glucose homeostasis, insulin sensitivity, and lipid metabolism in a rat streptozotocin-induced diabetes model.

Physicochemical Properties

Molecular Formula	C21H16N4O3S2
Molecular Weight	436.51
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Expression of PPAR-γ TF by newly synthesized thiazolidine-2,4-diones to manage glycemic control: Insights from in silico, in vitro and experimental pharmacology in wistar rats. Bioorg Chem. 2024 Dec;153:107966.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.2909 mL	11.4545 mL	22.9090 mL
	5 mM	0.4582 mL	2.2909 mL	4.5818 mL
	10 mM	0.2291 mL	1.1454 mL	2.2909 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.