PPARγ agonist 14 (compound 3) is a PPARy agonist (EC50=2.4 μM) with anti-diabetic activity. PPARγ agonist 14 can improve intracellular glucose uptake, promote insulin release, and lower blood sugar. In addition, PPARγ agonist 14 also participates in improving mitochondrial function, reducing oxidative stress and inhibiting inflammatory factors. PPARγ agonist 14 can be used in the study of neurodegenerative diseases, neuroinflammatory diseases and other diseases.

Physicochemical Properties

Molecular Formula	C17H16O6
Molecular Weight	316.31
CAS #	6951-57-1
Appearance	Solid powder
SMILES	COC1=C(C(=C2C(=O)CC(OC2=C1)C3=CC=C(C=C3)O)OC)O
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	PPARγ 2.4 μM (EC50)
References	[1]. Novel application of flavanone compound. CN106580951. 2016-11-17https://patents.google.com/patent/CN106580951A/en?oq=CN106580951.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.1615 mL	15.8073 mL	31.6146 mL
	5 mM	0.6323 mL	3.1615 mL	6.3229 mL
	10 mM	0.3161 mL	1.5807 mL	3.1615 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.