PLGA (50:50) (poly(lactic-co-glycolic acid) (50:50)) is a copolymer of polylactic acid (PLA) and polyglycolic acid (PGA) that can be manufactured for drug delivery and tissue engineering applications installation.

Physicochemical Properties

Molecular Formula	(C3H6O3.C2H4O3)N
Molecular Weight	166.1293
CAS #	34346-01-5
Related CAS #	PLGA (75:25);34346-01-5
PubChem CID	36797
Appearance	White to off-white solid powder
Density	1.53 g/mL at 25 °C(lit.)
Melting Point	262 °C(lit.)
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	6
Rotatable Bond Count	2
Heavy Atom Count	11
Complexity	99.2
Defined Atom Stereocenter Count	0
SMILES	0
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Poly Lactic-co-Glycolic Acid (PLGA) as Biodegradable Controlled Drug Delivery Carrier. Polymers (Basel). 2011 Sep 1;3(3):1377-1397. [2]. Chung TW, Tsai YL, Hsieh JH, Tsai WJ. Different ratios of lactide and glycolide in PLGA affect the surface property and protein delivery characteristics of the PLGA microspheres with hydrophobic additives. J Microencapsul. 2006;23(1):15-27.
Additional Infomation	A polyester used for absorbable sutures and surgical mesh, especially in ophthalmic surgery. 2-Hydroxy-propanoic acid polymer with polymerized hydroxyacetic acid, which forms 3,6-dimethyl-1,4-dioxane-dione polymer with 1,4-dioxane-2,5-dione copolymer of molecular weight about 80,000 daltons. See also: Polyglactin 910 (annotation moved to).

Solubility Data

Solubility (In Vitro)

DMSO : ~25 mg/mL Ethanol :< 1 mg/mL H2O : < 0.1 mg/mL

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (Infinity mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.0194 mL	30.0969 mL	60.1938 mL
	5 mM	1.2039 mL	6.0194 mL	12.0388 mL
	10 mM	0.6019 mL	3.0097 mL	6.0194 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.