PIYLGGVFQ is a peptide inhibitor of TNF-α. PIYLGGVFQ inhibits TNF-α-mediated apoptosis, NF-κB nuclear translocation and activation. PIYLGGVFQ exhibits anti-arthritis activity in a CIA mouse model.

Physicochemical Properties

Molecular Formula	C49H72N10O12
Molecular Weight	993.16
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Novel peptide inhibitor of human tumor necrosis factor-α has antiarthritic activity. Sci Rep. 2024 Jun 5;14(1):12935.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.0069 mL	5.0344 mL	10.0689 mL
	5 mM	0.2014 mL	1.0069 mL	2.0138 mL
	10 mM	0.1007 mL	0.5034 mL	1.0069 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.