PH-HG-005-5 can be used for ADC synthesis.

Physicochemical Properties

Molecular Formula	C41H47N7O10
Molecular Weight	797.852790117264
CAS #	2810895-93-1
PubChem CID	169688179
Appearance	Light yellow to yellow solid powder
Hydrogen Bond Donor Count	6
Hydrogen Bond Acceptor Count	12
Rotatable Bond Count	16
Heavy Atom Count	58
Complexity	1660
Defined Atom Stereocenter Count	3
SMILES	O([C@@]1(C(=O)OCC2C(N3CC4C(=C5C=C(O)C=CC5=NC=4C3=CC1=2)CC)=O)CC)C(=O)OCC1C=CC(NC(=O)[C@H](CCCNC(=O)N)NC(=O)[C@@H](N)C(C)C)=CC=1
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. EphA2 bicyclic peptide ligand and conjugate thereof. World Intellectual Property Organization, WO2023061482 A1. 2023-04-20.

Solubility Data

Solubility (In Vitro)

DMSO: 150 mg/mL (188.01 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 3.75 mg/mL (4.70 mM) (saturation unknown) in 10% DMSO + 40% PEG300 +5% Tween-80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 37.5 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 + to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.2534 mL	6.2668 mL	12.5337 mL
	5 mM	0.2507 mL	1.2534 mL	2.5067 mL
	10 mM	0.1253 mL	0.6267 mL	1.2534 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.