PCNA-IN-1 (Compound 11) is a PCNA/PIP-box interaction inhibitor with IC50 of >50 μM. PCNA-IN-1 can be used in cancer research.

Physicochemical Properties

Molecular Formula	C19H18I3NO3
Molecular Weight	689.06
CAS #	1417653-45-2
Appearance	Solid powder
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage.(2). Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis. Bioorg Med Chem. 2013 Apr 1;21(7):1972-7.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.4513 mL	7.2563 mL	14.5125 mL
	5 mM	0.2903 mL	1.4513 mL	2.9025 mL
	10 mM	0.1451 mL	0.7256 mL	1.4513 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.