PARP1-IN-35 (compound T26) is a selective, orally active, blood-brain-permeable PARP1 inhibitor with IC50 values of 0.2 and 122 nM for PARP1 and PARP2, respectively. PARP1-IN-35 has antiproliferative and anticancer activities. PARP1-IN-35 has the potential to be used in breast cancer research.

Physicochemical Properties

Molecular Formula	C22H21N5O
Molecular Weight	371.44
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	PARP1 0.2 nM (IC50); PARP2 122 nM (IC50)
References	[1]. Design, Synthesis, and Pharmacodynamic Evaluation of Highly Selective PARP1 Inhibitors with Brain Penetrance. J Med Chem. 2025 Jan 10.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.6922 mL	13.4611 mL	26.9222 mL
	5 mM	0.5384 mL	2.6922 mL	5.3844 mL
	10 mM	0.2692 mL	1.3461 mL	2.6922 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.