PAMAM dendrimer G1.5 carboxylate (PAMAM G1.5 carboxylate) sodium is a polyanionic dendrimer composed of sodium terminal carboxylates. PAMAM dendrimer G1.5 carboxylate exhibits antiviral activity in the MERS-CoV plaque inhibition assay with an inhibition rate of 40.5%.

Physicochemical Properties

Molecular Formula	C110H176N26NA16O44
Molecular Weight	2934.56
CAS #	251970-28-2
Synonyms	PAMAM G1.5 carboxylate sodium
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Use of Half-Generation PAMAM Dendrimers (G0.5–G3.5) with Carboxylate End-Groups to Improve the DACHPtCl2 and 5-FU Efficacy as Anticancer Drugs. Molecules. 2021 May 14;26(10):2924.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.3408 mL	1.7038 mL	3.4077 mL
	5 mM	0.0682 mL	0.3408 mL	0.6815 mL
	10 mM	0.0341 mL	0.1704 mL	0.3408 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.