P315V3 is a pan-coronavirus inhibitor that inhibits SARS-CoV-2 prototype PT, Delta, BA.1, and BA.4 strains with IC50 of 10.9, 8.9, 8.6, and 2.7 nM, respectively. P315V3 exhibits cytotoxicity in Vero cells with a CC50 of 4.3 μM. P315V3 exhibits anti-infective activity in mouse models.

Physicochemical Properties

Molecular Formula	C241H407N59O80S
Molecular Weight	5443.22
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. A pan-coronavirus peptide inhibitor prevents SARS-CoV-2 infection in mice by intranasal delivery. Sci China Life Sci. 2023 Oct;66(10):2201-2213.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	0.1837 mL	0.9186 mL	1.8371 mL
	5 mM	0.0367 mL	0.1837 mL	0.3674 mL
	10 mM	0.0184 mL	0.0919 mL	0.1837 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.