Oxypeucedanin is a furanocoumarin analogue extracted from Angelica dahurica. Oxypeucedanin is a selective open channel blocker that can inhibit hKv1.5 channel current with IC50 of 76 nM. Oxypeucedanin prolongs cardiac action potential duration (APD) and is a potential antiarrhythmic agent. Oxypeucedanin causes apoptosis by inhibiting cancer/tumor cell migration.

Physicochemical Properties

Molecular Formula	C16H14O5
Molecular Weight	286.2794
Exact Mass	286.084
CAS #	737-52-0
Related CAS #	737-52-0
PubChem CID	160544
Appearance	White to off-white solid
Density	1.4±0.1 g/cm3
Boiling Point	469.6±45.0 °C at 760 mmHg
Melting Point	141-142 °C
Flash Point	237.8±28.7 °C
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.634
LogP	2.17
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	3
Heavy Atom Count	21
Complexity	471
Defined Atom Stereocenter Count	0
SMILES	O1C([H])(C([H])([H])OC2=C3C([H])=C([H])C(=O)OC3=C([H])C3=C2C([H])=C([H])O3)C1(C([H])([H])[H])C([H])([H])[H]
InChi Key	QTAGQHZOLRFCBU-UHFFFAOYSA-N
InChi Code	InChI=1S/C16H14O5/c1-16(2)13(21-16)8-19-15-9-3-4-14(17)20-12(9)7-11-10(15)5-6-18-11/h3-7,13H,8H2,1-2H3
Chemical Name	4-[(3,3-dimethyloxiran-2-yl)methoxy]furo[3,2-g]chromen-7-one
Synonyms	Oxypeucedanin
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	hKv1.5 channel
References	[1]. Effects of oxypeucedanin on hKv1.5 and action potential duration.Biol Pharm Bull. 2005 Apr;28(4):657-60. [2]. Oxypeucedanin hydrate monoacetate isolated from Angelica dahurica induces apoptosis in Caco-2 colon carcinoma cells through the mediation of PI3K-signalling pathway and inhibition of cancer cell migration.
Additional Infomation	(R)-Oxypeucedanin is a member of psoralens. 4-[(3,3-Dimethyloxiran-2-yl)methoxy]furo[3,2-g]chromen-7-one has been reported in Citrus medica, Prangos latiloba, and other organisms with data available. See also: Oxypeucedanin (annotation moved to).

Solubility Data

Solubility (In Vitro)

DMSO: 24~50 mg/mL (83.8~174.7 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (8.73 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.73 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.4931 mL	17.4654 mL	34.9308 mL
	5 mM	0.6986 mL	3.4931 mL	6.9862 mL
	10 mM	0.3493 mL	1.7465 mL	3.4931 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.