Ovalitenone is a flavonoid isolated from the plant Millettia peguensis. Ovalitenone had no cytotoxic effect on lung cancer H460 and A549 cells, but significantly inhibited anchorage-independent growth, CSC-like phenotype, colony formation, and the ability of cancer cells to migrate and invade. Ovalitenone significantly reduced the levels of N-cadherin, snail, and slug, while increasing E-cadherin and inhibiting the EMT pathway. Ovalitenone also inhibited the regulatory signaling pathways of pyro-attachment kinase (FAK), ATP-dependent tyrosine kinase (AKT), mammalian target of rapamycin (mTOR), and cell division cycle 42 (Cdc42).

Physicochemical Properties

Molecular Formula	C19H14O6
Molecular Weight	338.31
CAS #	64280-22-4
SMILES	O1C=CC2=C1C=CC(C(CC(C1C=CC3=C(C=1)OCO3)=O)=O)=C2OC
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Ovalitenone Inhibits the Migration of Lung Cancer Cells via the Suppression of AKT/mTOR and Epithelial-to-Mesenchymal Transition. Molecules. 2021, 26, 638. [2]. Flavonoids from Millettia peguensis Ali (Fabaceae). Biochemical Systematics and Ecology 26 (1998) 125-126.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.9559 mL	14.7793 mL	29.5587 mL
	5 mM	0.5912 mL	2.9559 mL	5.9117 mL
	10 mM	0.2956 mL	1.4779 mL	2.9559 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.