Octadecanedioic acid is an endogenously produced metabolite, a long-chain dicarboxylic acid that has been found in serum free fatty acids in Reye's syndrome.

Physicochemical Properties

Molecular Formula	C₁₈H₃₄O₄
Molecular Weight	314.46
Exact Mass	314.245
CAS #	871-70-5
PubChem CID	70095
Appearance	White to off-white solid powder
Density	1.0±0.1 g/cm3
Boiling Point	480.9±18.0 °C at 760 mmHg
Melting Point	125°C
Flash Point	258.8±17.7 °C
Vapour Pressure	0.0±2.6 mmHg at 25°C
Index of Refraction	1.474
LogP	6.11
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	17
Heavy Atom Count	22
Complexity	248
Defined Atom Stereocenter Count	0
InChi Key	BNJOQKFENDDGSC-UHFFFAOYSA-N
InChi Code	InChI=1S/C18H34O4/c19-17(20)15-13-11-9-7-5-3-1-2-4-6-8-10-12-14-16-18(21)22/h1-16H2,(H,19,20)(H,21,22)
Chemical Name	octadecanedioic acid
Synonyms	Octadecanedioic acid; Octadecanedioic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References	[1]. Tonsgard JH. Serum dicarboxylic acids in patients with Reye syndrome. J Pediatr. 1986 Sep;109(3):440-5.
Additional Infomation	Octadecanedioic acid is an alpha,omega-dicarboxylic acid that is octadecane in which both terminal methyl groups have been replaced by carboxy groups. It is an alpha,omega-dicarboxylic acid and an octadecane. It is a conjugate acid of an octadecanedioate and an octadecanedioic acid anion. Octadecanedioic acid has been reported in Arabidopsis thaliana and Pinus radiata with data available.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~318.01 mM)

Solubility (In Vivo)

Solubility in Formulation 1: 2.5 mg/mL (7.95 mM) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), suspension solution; with sonication. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (7.95 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.1801 mL	15.9003 mL	31.8005 mL
	5 mM	0.6360 mL	3.1801 mL	6.3601 mL
	10 mM	0.3180 mL	1.5900 mL	3.1801 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.