OPC 4392 hydrochloride is an agonist of presynaptic dopamine receptors and an antagonist of postsynaptic D2 receptors. OPC 4392 reverses reserpine-induced dopamine accumulation and inhibits stereotypic and climbing behaviors in apomorphine-induced mouse models.

Physicochemical Properties

Molecular Formula	C24H30CLN3O2
Molecular Weight	427.97
CAS #	1329509-60-5
Appearance	Typically exists as solids at room temperature
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). Please store this product in a sealed and protected environment, avoid exposure to moisture.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Yasuda Y, et al., 7-[3-(4-[2,3-Dimethylphenyl]piperazinyl)propoxy]-2(1H)-quinolinone (OPC-4392), a presynaptic dopamine autoreceptor agonist and postsynaptic D2 receptor antagonist. Life Sci. 1988;42(20):1941-54.

Solubility Data

Solubility (In Vitro)

DMSO : ~50 mg/mL (~116.83 mM; with ultrasonication)

Solubility (In Vivo)

Solubility in Formulation 1: 4.3 mg/mL (10.05 mM) in Lactic acid buffer (50 mM, pH 4.0) (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication。 Solubility in Formulation 2: 4.3 mg/mL (10.05 mM) in Lactated Ringers solution (add these co-solvents sequentially from left to right, and one by one), clear solution; with ultrasonication。  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.3366 mL	11.6831 mL	23.3661 mL
	5 mM	0.4673 mL	2.3366 mL	4.6732 mL
	10 mM	0.2337 mL	1.1683 mL	2.3366 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.