OMS14 has an inhibitory effect on phosphoinositide 3-kinase γ (PI3Kγ) and PIK3CD/PIK3R1, inhibiting 19% PI3Kγ and 65% PIK3CD/PIK3R1 activity at 100 μM. OMS14 exhibits anticancer effects against a variety of cancer cells.

Physicochemical Properties

Molecular Formula	C21H22N6O4S
Molecular Weight	454.50
Appearance	White to off-white solid powder
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	PI3Kγ
ln Vitro	OMS14 (0-100 μM) inhibits the proliferation of A549 and MCF-7 cells with IC50 values of 22.13 and 26.09 μM, respectively[1]. OMS14 (100 μg/mL) inhibits the formation of Staphylococcus aureus colonies with a diameter of 15 mm[1].
Cell Assay	Cell Viability Assay[1] Cell Types: A549 and MCF-7 Tested Tested Concentrations: 0-100 μM Incubation Duration: 72 h Experimental Results: Inhibited cell proliferations.
References	[1]. Novel 2-Aminobenzothiazole Derivatives: Docking, Synthesis, and Biological Evaluation as Anticancer AgentsJ. ACS Omega, 2024.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~220.02 mM; with ultrasonication (<60°C))

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 5 mg/mL (11.00 mM)(saturation unknown) in 10% DMSO 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one),clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 50.0 mg/mL clear DMSO stock solution and add it to 900 μL corn oil and mix well.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	2.2002 mL	11.0011 mL	22.0022 mL
	5 mM	0.4400 mL	2.2002 mL	4.4004 mL
	10 mM	0.2200 mL	1.1001 mL	2.2002 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.