Nortropine (Nortropenol) can be extracted from Convolvulus subhirsutus alkaloids and is an intermediate in the decomposition and reaction of tropine base to produce succinic acid.

Physicochemical Properties

Molecular Formula	C7H13NO
Molecular Weight	127.1842
Exact Mass	122.073
CAS #	538-09-0
PubChem CID	73480
Appearance	Off-white to light brown solid powder
Density	1.0±0.1 g/cm3
Boiling Point	218.2±8.0 °C at 760 mmHg
Melting Point	108-110ºC
Flash Point	102.2±0.0 °C
Vapour Pressure	0.1±0.5 mmHg at 25°C
Index of Refraction	1.536
LogP	1.36
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Heavy Atom Count	9
Complexity	104
Defined Atom Stereocenter Count	2
SMILES	C1C[C@H]2CC(C[C@@H]1N2)O
InChi Key	YYMCYJLIYNNOMK-MEKDEQNOSA-N
InChi Code	InChI=1S/C7H13NO/c9-7-3-5-1-2-6(4-7)8-5/h5-9H,1-4H2/t5-,6+,7?
Chemical Name	(1R,5S)-8-azabicyclo[3.2.1]octan-3-ol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Atropine Metabolism by Pseudomonas sp. Strain AT3: Evidence for Nortropine as an Intermediate in Tropine Breakdown and Reactions Leading to Succinate. Appl Environ Microbiol. 1996 Sep;62(9):3245-50. [2]. Alkaloids of Convolvulus subhirsutus from Uzbekistan. Chemistry of Natural Compounds. 2007. 43(3):291-292.

Solubility Data

Solubility (In Vitro)

DMSO : ~33.33 mg/mL (~262.07 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (19.66 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (19.66 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	7.8629 mL	39.3144 mL	78.6287 mL
	5 mM	1.5726 mL	7.8629 mL	15.7257 mL
	10 mM	0.7863 mL	3.9314 mL	7.8629 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.