Norquetiapine is an antidepressant and neuroprotectant, and is the active metabolite of Quetiapine. Norquetiapine is also a partial 5-HT1A receptor agonist, and an antagonist of presynaptic α2, 5-HT2C, and 5-HT7 receptors. Norquetiapine can also selectively inhibit the norepinephrine transporter (NET), inhibiting norepinephrine reuptake, and has potential inhibitory effects on bipolar depression, major depressive disorder, and generalized anxiety disorder. Norquetiapine showed in vivo activity in the mouse forced swim and rat learned helplessness tests.

Physicochemical Properties

Molecular Formula	C17H17N3S
Molecular Weight	295.40
CAS #	5747-48-8
Appearance	Solid Powder
SMILES	S1C2=C([H])C([H])=C([H])C([H])=C2N=C(C2=C([H])C([H])=C([H])C([H])=C12)N1C([H])([H])C([H])([H])N([H])C([H])([H])C1([H])[H]
Synonyms	N-Desalkylquetiapine
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: (1). This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. López-Muñoz F, et al. Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders. Front Psychiatry. 2013 Sep 12;4:102. [2]. Quetiapine and its metabolite norquetiapine: translation from in vitro pharmacology to in vivo efficacy in rodent models. Br J Pharmacol. 2016 Jan;173(1):155-66.

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~338.52 mM; with ultrasonication)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (8.46 mM) (saturation unknown) in 10% DMSO +90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution。 For example, if 1 mL of working solution is to be prepared, You can add 100 μL of the 25.0 mg/mL clear DMSO stock solution to 900 μL corn oil and mix well.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.3852 mL	16.9262 mL	33.8524 mL
	5 mM	0.6770 mL	3.3852 mL	6.7705 mL
	10 mM	0.3385 mL	1.6926 mL	3.3852 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.