Nonadecanoic acid is a 19 C-long saturated fatty acid, which is the main substance secreted by Rhinotermes marginalis during defense.

Physicochemical Properties

Molecular Formula	C19H38O2
Molecular Weight	298.5038
Exact Mass	298.287
CAS #	646-30-0
Related CAS #	Nonadecanoic acid-d37;1219798-49-8
PubChem CID	12591
Appearance	White to off-white solid powder
Density	0.9±0.1 g/cm3
Boiling Point	368.1±5.0 °C at 760 mmHg
Melting Point	68-70 °C(lit.)
Flash Point	166.1±12.5 °C
Vapour Pressure	0.0±0.9 mmHg at 25°C
Index of Refraction	1.457
LogP	8.75
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	17
Heavy Atom Count	21
Complexity	214
Defined Atom Stereocenter Count	0
InChi Key	ISYWECDDZWTKFF-UHFFFAOYSA-N
InChi Code	InChI=1S/C19H38O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19(20)21/h2-18H2,1H3,(H,20,21)
Chemical Name	nonadecanoic acid
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Biochemistry of termite defenses: Coptotermes, rhinotermes and Cornitermes species. Comparative Biochemistry and Physiology Part B: Comparative Biochemistry. 1982.

Additional Infomation

Nonadecanoic acid is a C19 straight-chain fatty acid of plant or bacterial origin. An intermediate in the biodegradation of n-icosane, it has been shown to inhibit cancer growth. It has a role as a fungal metabolite. It is a straight-chain saturated fatty acid and a long-chain fatty acid. It is a conjugate acid of a nonadecanoate. Nonadecanoic acid has been reported in Solanum tuberosum, Streptomyces, and other organisms with data available. See also: Fatty acids, C16-22 (annotation moved to).

Solubility Data

Solubility (In Vitro)

DMSO : ~100 mg/mL (~335.01 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (8.38 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (8.38 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	3.3501 mL	16.7504 mL	33.5008 mL
	5 mM	0.6700 mL	3.3501 mL	6.7002 mL
	10 mM	0.3350 mL	1.6750 mL	3.3501 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.