Neuropeptide Y (human) TFA is associated with Alzheimer's disease (AD) and protects mouse cortical neurons against amyloid toxicity.

Physicochemical Properties

Molecular Formula	C191H286F3N55O59S
Related CAS #	Neuropeptide Y (human);90880-35-6;[D-Arg25]-Neuropeptide Y (human)
Appearance	Typically exists as solid at room temperature
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: Please store this product in a sealed and protected environment (e.g. under nitrogen), avoid exposure to moisture and light.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro

It has been demonstrated that neuropeptide Y (human) can shield cortical neurons from the toxicity of Aβ25–35. At 24 and 48 hours, the harmful effects of Aβ25-35 are eliminated by 2 μM NPY. When neurons are pretreated with 1 μM and 0.5 μM Neuropeptide Y(human), the same effect is seen on neuronal survival. In cortical neurons exposed to Aβ35-25, pretreatment with Neuropeptide Y(29-64), amide, human (TFA) increases NGF synthesis, lowers NGF mRNA, and restores NGF release[1].

References

[1]. Croce N, et al. Neuropeptide Y protects rat cortical neurons against β-amyloid toxicity and re-establishes synthesis and release of nerve growth factor. ACS Chem Neurosci. 2012 Apr 18;3(4):312-8.

Solubility Data

Solubility (In Vitro)	H2O :~100 mg/mL (~22.80 mM)
Solubility (In Vivo)	Solubility in Formulation 1: 100 mg/mL (22.80 mM) in PBS (add these co-solvents sequentially from left to right, and one by one), clear solution; with sonication.  (Please use freshly prepared in vivo formulations for optimal results.)