Naphthoresorcinol (1,3-Dihydroxynaphthalene) is a fluorescent dye (λex=330 nm, λem=380 nm) that reacts with NPPD (a tracer) and concentrated HCl and displays a red color. Naphthoresorbinol can also be used as a background electrolyte (BGE) for carbohydrate determination.

Physicochemical Properties

Molecular Formula	C10H8O2
Molecular Weight	160.17
Exact Mass	160.052
CAS #	132-86-5
PubChem CID	8601
Appearance	Light yellow to brown solid powder
Density	1.3±0.1 g/cm3
Boiling Point	361.5±9.0 °C at 760 mmHg
Melting Point	123-125 °C(lit.)
Flash Point	185.5±13.3 °C
Vapour Pressure	0.0±0.8 mmHg at 25°C
Index of Refraction	1.726
LogP	1.99
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	2
Rotatable Bond Count	0
Heavy Atom Count	12
Complexity	158
Defined Atom Stereocenter Count	0
InChi Key	XOOMNEFVDUTJPP-UHFFFAOYSA-N
InChi Code	InChI=1S/C10H8O2/c11-8-5-7-3-1-2-4-9(7)10(12)6-8/h1-6,11-12H
Chemical Name	naphthalene-1,3-diol
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month Note: This product requires protection from light (avoid light exposure) during transportation and storage.
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

References

[1]. Fluorescence and light scattering studies on the interaction of 1,3-dihydroxynaphthalene with ionic and non-ionic surfactants. Polymer Photochemistry. 1984; 4(4):245-253. [2]. Development of a field kit for use by non-scientists for chemical tracking using 5-(4-nitrophenyl)-2,4-pentadien-1-al. Forensic Sci Int. 2013 May 10;228(1-3):e25-7. [3]. Determination of carbohydrates by high-performance capillary electrophoresis with indirect absorbance detection. J Chromatogr B Biomed Appl. 1996 May 31;681(1):87-97.

Additional Infomation

1,3-Naphthalenediol has been reported in Salvia officinalis and Magnolia liliiflora with data available.

Solubility Data

Solubility (In Vitro)

DMSO: 100 mg/mL (624.34 mM)

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.5 mg/mL (15.61 mM) (saturation unknown) in 10% DMSO + 40% PEG300 + 5% Tween80 + 45% Saline (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 400 μL PEG300 and mix evenly; then add 50 μL Tween-80 to the above solution and mix evenly; then add 450 μL normal saline to adjust the volume to 1 mL. Preparation of saline: Dissolve 0.9 g of sodium chloride in 100 mL ddH₂ O to obtain a clear solution. Solubility in Formulation 2: ≥ 2.5 mg/mL (15.61 mM) (saturation unknown) in 10% DMSO + 90% (20% SBE-β-CD in Saline) (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 25.0 mg/mL clear DMSO stock solution to 900 μL of 20% SBE-β-CD physiological saline solution and mix evenly. Preparation of 20% SBE-β-CD in Saline (4°C，1 week): Dissolve 2 g SBE-β-CD in 10 mL saline to obtain a clear solution.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	6.2434 mL	31.2168 mL	62.4337 mL
	5 mM	1.2487 mL	6.2434 mL	12.4867 mL
	10 mM	0.6243 mL	3.1217 mL	6.2434 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.