Naph-Se-TMZ is a PROTAC-like HDAC1 degrader. Naph-Se-TMZ can reduce the total HDAC activity in glioma cells and enhance the inhibitory effect of Temozolomide. Naph-Se-TMZ consists of the target protein ligand (red part) Temozolomide, the DNA intercalator (blue part) Nitro-Naphthalimide-C2-acylamide and the molecular linker (black part). At the same time, the active control of the target protein ligand is: Temozolomide-amino hydrochloride, and the DNA targeted insertion molecule + linker is: NNISC-2.

Physicochemical Properties

Molecular Formula	C21H16N10O6SE
Molecular Weight	583.38
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

Targets	HDAC1 Cereblon
References	[1]. Synthesis and characterization of a novel Naphthalimide-Selenium based Temozolomide drug conjugate in glioma cells. Bioorg Chem. 2024 Nov 26;154:107998.

Solubility Data

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.7141 mL	8.5707 mL	17.1415 mL
	5 mM	0.3428 mL	1.7141 mL	3.4283 mL
	10 mM	0.1714 mL	0.8571 mL	1.7141 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.