NY2267 is a Myc-Max interaction interferent with IC50 of 36.5 μM. NY2267 inhibits Myc- and Jun-induced transcriptional activation.

Physicochemical Properties

Molecular Formula	C38H43N3O6
Molecular Weight	637.764530420303
Exact Mass	637.315
CAS #	886053-73-2
PubChem CID	12000419
Appearance	Off-white to light yellow ointment
LogP	7.1
Hydrogen Bond Donor Count	1
Hydrogen Bond Acceptor Count	7
Rotatable Bond Count	13
Heavy Atom Count	47
Complexity	1020
Defined Atom Stereocenter Count	0
InChi Key	RVGDACCXDZIPOB-UHFFFAOYSA-N
InChi Code	InChI=1S/C38H43N3O6/c1-38(2,3)47-34(42)25-46-32-20-17-27-22-29(16-15-28(27)23-32)35(36(43)40-30-10-6-5-7-11-30)41(37(44)33-12-8-9-21-39-33)24-26-13-18-31(45-4)19-14-26/h8-9,12-23,30,35H,5-7,10-11,24-25H2,1-4H3,(H,40,43)
Chemical Name	tert-butyl 2-[6-[2-(cyclohexylamino)-1-[(4-methoxyphenyl)methyl-(pyridine-2-carbonyl)amino]-2-oxoethyl]naphthalen-2-yl]oxyacetate
HS Tariff Code	2934.99.9001
Storage	Powder-20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Shipping Condition	Room temperature (This product is stable at ambient temperature for a few days during ordinary shipping and time spent in Customs)

Biological Activity

ln Vitro	NY2267 strongly prevents the oncogenic transformation caused by Myc [1].
References	[1]. A credit-card library approach for disrupting protein-protein interactions. Bioorg Med Chem. 2006 Apr 15;14(8):2660-73.

Solubility Data

Solubility (In Vitro)

DMSO : 250 mg/mL (392.00 mM )

Solubility (In Vivo)

Solubility in Formulation 1: ≥ 2.08 mg/mL (3.26 mM) (saturation unknown) in 10% DMSO + 90% Corn Oil (add these co-solvents sequentially from left to right, and one by one), clear solution. For example, if 1 mL of working solution is to be prepared, you can add 100 μL of 20.8 mg/mL clear DMSO stock solution to 900 μL of corn oil and mix evenly.  (Please use freshly prepared in vivo formulations for optimal results.)

Preparing Stock Solutions		1 mg	5 mg	10 mg
	1 mM	1.5680 mL	7.8399 mL	15.6799 mL
	5 mM	0.3136 mL	1.5680 mL	3.1360 mL
	10 mM	0.1568 mL	0.7840 mL	1.5680 mL

*Note: Please select an appropriate solvent for the preparation of stock solution based on your experiment needs. For most products, DMSO can be used for preparing stock solutions (e.g. 5 mM, 10 mM, or 20 mM concentration); some products with high aqueous solubility may be dissolved in water directly. Solubility information is available at the above Solubility Data section. Once the stock solution is prepared, aliquot it to routine usage volumes and store at -20°C or -80°C. Avoid repeated freeze and thaw cycles.